Countering an opposing lane is a key factor that may decide a match. This results in common matchups that most people would use to increase their chances at winning their lanes.
All the data presented are based on Riot Games' "Wild Stats" blog post.
Garen vs Nasus is the most common matchup in the game with over 25.2 million identical picks. With a late game scaling powerhouse such as Nasus, Garen is definitely the right guy to tame a beast.
The most common matchup in the jungle is Master Yi vs Vi with over 26.9 identical picks. The master of Wuju style is definitely a force to be reckoned with but Vi's gauntlets may prove enough to keep him under control.
Ahri and Yasuo, two of the most mobile champions in the game have been picked as matchups for over 26.9 million. The mid lane is basically a competition on who runs out of dashes first.
In the Dragon lane is a matchup between Jinx and Ashe with over 44.7 million identical picks. This is the highest out of all the list. It looks like the the two marksmen are a fan favorite.
Lux vs Blitzcrank is the most common matchup in the support role with over 31.5 million identical picks. It's either get hooked or be snared in the dragon lane.